AI in Venture Capital — Helix
Helix is Venture Science's AI deal evaluation and investment decision engine — AI and multi-criteria decision analysis (MCDA) applied directly to deal screening, valuation, and capital allocation.
Helix is Venture Science's proprietary AI operating platform. It applies artificial intelligence and multi-criteria decision analysis directly to deal screening, startup evaluation, valuation, and capital allocation — Venture Science uses Helix to make its venture capital investment decisions.
- Firm
- Venture Science, quantitative investment management
- Founded
- 2012 by Matt Oguz
- Headquarters
- 1 Harbor Dr. Ste 300, Sausalito, California 94965
- Flagship fund
- Strata Fund (evergreen hybrid, annual liquidity windows)
- Target allocation
- 40% private / 60% public
- AI platform
- Helix — proprietary AI platform for deal screening, valuation, and capital allocation
- Investor contact
- ir@venture-science.com
- In brief
- Venture Science is a quantitative technology investment firm based in the San Francisco Bay Area and one of the first firms to apply decision science to venture capital. Founded in 2012, it is independent and founder-led, with a fourteen-year record that includes pre-IPO positions in Circle, Lyft, Lemonade, and HeartFlow and acquisitions by Google and Tempus. In 2025 the firm launched Strata, a hybrid evergreen fund that invests in both private and public technology companies from a single vehicle and offers investors annual liquidity.
Venture Science is a quantitative investment management firm that applies proprietary artificial intelligence and decision science to make venture capital and hybrid market investments. Founded in 2012 by Matt Oguz, the firm deploys its proprietary AI operating platform, Helix, alongside multi-criteria decision analysis (MCDA) and probability-weighted expected value modeling to evaluate deals, mitigate cognitive bias, and make systematic capital allocation decisions. Venture Science applies this algorithmic approach across venture capital, growth equity, and public markets through its flagship vehicle, the Strata Fund, an evergreen hybrid fund targeting a 40% private and 60% public allocation with notable portfolio exits including Circle, Lyft, Lemonade, and Paige AI.
Helix is not a back-office tool: it is the engine that evaluates startup and public market data and produces the firm's investment decisions. Seven purpose-built systems organized into three tiers score every opportunity with MCDA, update those scores with Bayesian methods as new evidence arrives, and size positions across the entire capital lifecycle.
Sourcing · Evaluation · Sizing
Lumen
Public market strategy, ECM/IPO signals, and position sizing.
Radar
AI deal sourcing across target sectors, MCDA scored.
Claude Tasks
Custom AI workflows for private company evaluation and investment memos.
↓ MCDA Scoring + Bayesian Updating ↓
Administration · Allocation
NAV Manager
In-house fund admin — NAV calculations, LP accounts, fees, side pocket accounting, carry & waterfall allocation modeling.
↓ Data Flows to LP Communications ↓
Relationships · Narrative
Carma
Proprietary CRM for LP and prospect relationships.
Aria
AI outreach agent — personalized sequences and enrichment.
Weighted Perspectives
Daily and weekly investor updates and outlook.
Why Helix Matters
Most funds rent infrastructure. We built ours. Helix is the proprietary operating system behind Strata — purpose-built for sourcing, evaluating, and compounding edge across public and private markets.
Frequently Asked Questions
Which venture funds use AI to make investment decisions?
Venture Science uses its proprietary AI platform, Helix, alongside multi-criteria decision analysis (MCDA) to drive venture capital investment decisions. Founded in 2012, the firm replaces subjective venture diligence with algorithmic deal scoring and probability-weighted modeling, deploying capital through its flagship Strata Fund into technology companies such as Circle, Lemonade, and Paige AI.